TITLE: Effect of Lepidium meyenii (maca) roots on
spermatogenesis of male rats.
AUTHOR:
Gonzales,-G-F;
Ruiz,-A;
Gonzales,-C;
Villegas,-L;
Cordova,-A
ADDRESS OF AUTHOR:
Department of
Physiological Sciences, Faculty of Sciences and Philosophy, Universidad
Peruana Cayetano Heredia, Lima, Peru. iiad@upch.edu.pe
SOURCE:
Asian-J-Androl.
2001 Sep; 3(3): 231-3
JOURNAL NAME:
Asian-journal-of-andrology
INTERNATIONAL STANDARD SERIAL NUMBER:
1008-682X
PUBLICATION YEAR: 2001
LANGUAGE:
English
COUNTRY OF PUBLICATION:
China
MAIN ABSTRACT:
AIM: To
determine the effect of oral administration of an aqueous extract from the
roots of
Lepidium
meyenii
(maca) on spermatogenesis in adult male rats. METHODS: Male rats received
an aqueous extract of the root (66.7 mg in one mL) twice a day for 14
consecutive days. RESULTS: Treatment with
Lepidium
meyenii
resulted in an increase in the weights of testis and epididymis but not
the seminal vesicle weight. The length and frequency of stages IX-XIV
seminiferous tubules, where mitosis occurred, were increased and stages
I-VI were reduced in rats treated with
Lepidium
meyenii.
CONCLUSION: The
Lepidium
meyenii
root invigorates spermatogenesis in male rats by acting on its initial
stages (IX-XIV).
MAJOR MESH DESCRIPTORS:
*Lepidium-;
*Plant-Preparations-pharmacology;
*Spermatogenesis-drug-effects
MINOR MESH DESCRIPTORS:
Administration,-Oral;
Organ-Size;
Rats-;
Rats,-Sprague-Dawley;
Seminiferous-Epithelium-anatomy-and-histology;
Seminiferous-Epithelium-drug-effects
CHECK TAGS:
Animals;
Male
PUBLICATION TYPE:
Journal-Article
SUBHEADINGS:
pharmacology;
anatomy-and-histology;
drug-effects
CAS REGISTRY NUMBER:
0
PRIME NAME OF SUBSTANCE:
Plant-Preparations
JOURNAL CATEGORY:
Reproductive-Medicine; Urology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20011015
REVISION DATE:
20041117
COMPLETION DATE:
20020312
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
11561196
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
TITLE: Lepidium meyenii (Maca) improved semen parameters in
adult men.
AUTHOR:
Gonzales,-G-F;
Cordova,-A;
Gonzales,-C;
Chung,-A;
Vega,-K;
Villena,-A
ADDRESS OF AUTHOR:
Department of
Physiological Sciences, Faculty of Sciences and Philosophy and Instituto
de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia,
Lima, Peru. iiad@upch.edu.pe
SOURCE:
Asian-J-Androl.
2001 Dec; 3(4): 301-3
JOURNAL NAME:
Asian-journal-of-andrology
INTERNATIONAL STANDARD SERIAL NUMBER:
1008-682X
PUBLICATION YEAR: 2001
LANGUAGE:
English
COUNTRY OF PUBLICATION:
China
MAIN ABSTRACT:
AIM: The
present study was designed to determine the effect of a 4-month oral
treatment with tablets of
Lepidium
meyenii
(Maca) on seminal analysis in nine adult normal men aged 24-44 years old.
METHODS: Nine men received tablets of Maca (1500 or 3000 mg/day) for 4
months. Seminal analysis was performed according to guidelines of the
World Health Organization (WHO). Serum luteinizing hormone (LH), follicle
stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol
(E2) were measured before and after treatment. RESULTS: Treatment with
Maca resulted in increased seminal volume, sperm count per ejaculum,
motile sperm count, and sperm motility. Serum hormone levels were not
modified with Maca treatment. Increase of sperm count was not related to
dose of Maca. CONCLUSION: Maca improved sperm production and sperm
motility by mechanisms not related to LH, FSH, PRL, T and E2.
MAJOR MESH DESCRIPTORS:
*Lepidium-;
*Plant-Preparations-pharmacology;
*Semen-drug-effects
MINOR MESH DESCRIPTORS:
Adult-;
Estradiol-blood;
Follicle-Stimulating-Hormone-blood;
Luteinizing-Hormone-blood;
Phytotherapy-;
Prolactin-blood;
Semen-cytology;
Sperm-Count;
Sperm-Motility-drug-effects;
Testosterone-blood
AGE TAGS:
Adult
CHECK TAGS:
Humans;
Male
PUBLICATION TYPE:
Journal-Article
SUBHEADINGS:
blood;
pharmacology;
cytology;
drug-effects
CAS REGISTRY NUMBER:
0; 50-28-2;
58-22-0; 9002-62-4; 9002-67-9; 9002-68-0
PRIME NAME OF SUBSTANCE:
Plant-Preparations;
Estradiol;
Testosterone;
Prolactin;
Luteinizing-Hormone;
Follicle-Stimulating-Hormone
JOURNAL CATEGORY:
Reproductive-Medicine; Urology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20020111
REVISION DATE:
20041117
COMPLETION DATE:
20020709
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
11753476
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
TITLE: Effect of Lepidium meyenii (MACA) on sexual desire
and its absent relationship with serum testosterone levels in adult
healthy men.
AUTHOR:
Gonzales,-G-F;
Cordova,-A;
Vega,-K;
Chung,-A;
Villena,-A;
Gonez,-C;
Castillo,-S
ADDRESS OF AUTHOR:
Instituto de
Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima,
Peru. iiad@upch.edu.pe
SOURCE:
Andrologia.
2002 Dec; 34(6): 367-72
JOURNAL NAME:
Andrologia-
INTERNATIONAL STANDARD SERIAL NUMBER:
0303-4569
PUBLICATION YEAR: 2002
LANGUAGE:
English
COUNTRY OF PUBLICATION:
Germany
MAIN ABSTRACT:
This study
was a 12-week double blind placebo-controlled, randomized, parallel trial
in which active treatment with different doses of Maca Gelatinizada was
compared with placebo. The study aimed to demonstrate if effect of Maca on
subjective report of sexual desire was because of effect on mood or serum
testosterone levels. Men aged 21-56 years received Maca in one of two
doses: 1,500 mg or 3,000 mg or placebo. Self-perception on sexual desire,
score for Hamilton test for depression, and Hamilton test for anxiety were
measured at 4, 8 and 12 weeks of treatment. An improvement in sexual
desire was observed with Maca since 8 weeks of treatment. Serum
testosterone and oestradiol levels were not different in men treated with
Maca and in those treated with placebo (P:NS). Logistic regression
analysis showed that Maca has an independent effect on sexual desire at 8
and 12 weeks of treatment, and this effect is not because of changes in
either Hamilton scores for depression or anxiety or serum testosterone and
oestradiol levels. In conclusion, treatment with Maca improved sexual
desire.
MAJOR MESH DESCRIPTORS:
*Lepidium-;
*Phytotherapy-;
*Testosterone-blood
MINOR MESH DESCRIPTORS:
Adult-;
Middle-Aged;
Placebos-;
Reference-Values
AGE TAGS:
Adult;
Middle-Aged
CHECK TAGS:
Humans;
Male;
Research-Support,-Non-U.S.-Gov't
PUBLICATION TYPE:
Clinical-Trial; Journal-Article; Randomized-Controlled-Trial
SUBHEADINGS:
blood
CAS REGISTRY NUMBER:
0; 58-22-0
PRIME NAME OF SUBSTANCE:
Placebos;
Testosterone
JOURNAL CATEGORY:
Reproductive-Medicine; Urology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20021210
REVISION DATE:
20041117
COMPLETION DATE:
20030716
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
12472620
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
TITLE: Effect of Lepidium meyenii (Maca), a root with
aphrodisiac and fertility-enhancing properties, on serum reproductive
hormone levels in adult healthy men.
AUTHOR:
Gonzales,-G-F;
Cordova,-A;
Vega,-K;
Chung,-A;
Villena,-A;
Gonez,-C
ADDRESS OF AUTHOR:
Instituto de
Investigaciones de la Altura, and Department of Biological and
Physiological Sciences (Faculty of Sciences and Philosophy), Universidad
Peruana Cayetano Heredia, PO 1843, Lima, Peru.
SOURCE:
J-Endocrinol.
2003 Jan; 176(1): 163-8
JOURNAL NAME:
Journal-of-endocrinology,-The
INTERNATIONAL STANDARD SERIAL NUMBER:
0022-0795
PUBLICATION YEAR: 2003
LANGUAGE:
English
COUNTRY OF PUBLICATION:
England
MAIN ABSTRACT: Lepidium
meyenii
(Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and
4500 m in the central Andes. Maca is traditionally employed in the Andean
region for its supposed aphrodisiac and/or fertility-enhancing properties.
This study was a 12-week double-blind, placebo-controlled, randomized,
parallel trial in which active treatment with different doses of Maca
Gelatinizada was compared with a placebo. The study aimed to test the
hypothesis that Maca has no effect on serum reproductive hormone levels in
apparently healthy men when administered in doses used for aphrodisiac
and/or fertility-enhancing properties. Men aged between 21 and 56 Years
received 1500 mg or 3000 mg Maca. Serum levels of luteinizing hormone,
follicle-stimulating hormone, prolactin, 17-alpha hydroxyprogesterone,
testosterone and 17-beta estradiol were measured before and at 2, 4, 8 and
12 weeks of treatment with placebo or Maca (1.5 g or 3.0 g per day). Data
showed that compared with placebo Maca had no effect on any of the
hormones studied nor did the hormones show any changes over time. Multiple
regression analysis showed that serum testosterone levels were not
affected by treatment with Maca at any of the times studied (P, not
significant). In conclusion, treatment with Maca does not affect serum
reproductive hormone levels.
MAJOR MESH DESCRIPTORS:
*Aphrodisiacs-pharmacology;
*Gonadal-Steroid-Hormones-blood;
*Lepidium-;
*Plant-Roots
MINOR MESH DESCRIPTORS:
17-alpha-Hydroxyprogesterone-blood;
Adult-;
Double-Blind-Method;
Estradiol-blood;
Follicle-Stimulating-Hormone-blood;
Luteinizing-Hormone-blood;
Middle-Aged;
Peru-;
Prolactin-blood;
Regression-Analysis;
Testosterone-blood
AGE TAGS:
Adult;
Middle-Aged
CHECK TAGS:
Humans;
Male;
Research-Support,-U.S.-Gov't,-Non-P.H.S.
PUBLICATION TYPE:
Clinical-Trial; Journal-Article; Randomized-Controlled-Trial
SUBHEADINGS:
blood;
pharmacology
CAS REGISTRY NUMBER:
0; 0;
50-28-2; 58-22-0; 68-96-2; 9002-62-4; 9002-67-9; 9002-68-0
PRIME NAME OF SUBSTANCE:
Aphrodisiacs;
Gonadal-Steroid-Hormones;
Estradiol;
Testosterone;
17-alpha-Hydroxyprogesterone;
Prolactin;
Luteinizing-Hormone;
Follicle-Stimulating-Hormone
JOURNAL CATEGORY:
Endocrinology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20030114
REVISION DATE:
20041117
COMPLETION DATE:
20030303
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
12525260
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
TITLE: Effect of alcoholic extract of Lepidium meyenii (Maca)
on testicular function in male rats.
AUTHOR:
Gonzales,-G-F;
Rubio,-J;
Chung,-A;
Gasco,-M;
Villegas,-L
ADDRESS OF AUTHOR:
Department of
Biological and Physiological Sciences, Faculty of Sciences and Philosophy,
Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano
Heredia, Postal Office 1843, Lima, Peru. iiad@upch.edu.pe
SOURCE:
Asian-J-Androl.
2003 Dec; 5(4): 349-52
JOURNAL NAME:
Asian-journal-of-andrology
INTERNATIONAL STANDARD SERIAL NUMBER:
1008-682X
PUBLICATION YEAR: 2003
LANGUAGE:
English
COUNTRY OF PUBLICATION:
China
MAIN ABSTRACT:
AIM: To
evaluate the effect of the alcoholic extract of
Lepidium
meyenii
(Maca) on the spermatogenesis in male rats. METHODS: In Holtzman rats,
Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day
or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was
assessed by measurements of lengths of different stages of seminiferous
epithelia and by epididymal sperm count. RESULTS: Ethanolic extract of
Maca increased the length of stages IX-XI of seminiferous epithelium at
treatment day 7, day 14 and day 21. Progression of spermatogenesis was
evident only after day 21 when lengths of stages XII-XIV of seminiferous
epithelium were increased; at day 7 and day 14, no important change in
spermatogenesis was observed. Epididymal sperm count was increased with 48
mg/day at all times. With 96 mg/day an increase in sperm count was
observed at day 7, but it was reduced at day 14 and day 21 of treatment.
Serum testosterone levels were not affected. CONCLUSION: The alcoholic
extract of Maca activates onset ant progression of spermatogenesis at 48
mg/day or 96 mg/day in rats.
MAJOR MESH DESCRIPTORS:
*Ethanol-;
*Lepidium-chemistry;
*Plant-Extracts-pharmacology;
*Testis-drug-effects;
*Testis-physiology
MINOR MESH DESCRIPTORS:
Epididymis-cytology;
Plant-Extracts-administration-and-dosage;
Rats-;
Seminiferous-Epithelium-anatomy-and-histology;
Seminiferous-Epithelium-drug-effects;
Sperm-Count;
Spermatogenesis-drug-effects;
Testosterone-blood
CHECK TAGS:
Animals;
Male;
Research-Support,-Non-U.S.-Gov't
PUBLICATION TYPE:
Journal-Article
SUBHEADINGS:
cytology;
chemistry;
administration-and-dosage;
pharmacology;
anatomy-and-histology;
drug-effects;
physiology;
blood
CAS REGISTRY NUMBER:
0; 58-22-0;
64-17-5
PRIME NAME OF SUBSTANCE:
Plant-Extracts;
Testosterone;
Ethanol
JOURNAL CATEGORY:
Reproductive-Medicine; Urology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20031229
REVISION DATE:
20041117
COMPLETION DATE:
20040420
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
14695987
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
TITLE: Effect of Lepidium meyenii (Maca) on spermatogenesis
in male rats acutely exposed to high altitude (4340 m).
AUTHOR:
Gonzales,-G-F;
Gasco,-M;
Cordova,-A;
Chung,-A;
Rubio,-J;
Villegas,-L
ADDRESS OF AUTHOR:
Instituto de
Investigaciones de la Altura, and Departamento de Ciencias Biologicas y
Fisiologicas, Facultad de Ciencas y Filosofia, Universidad Peruana
Cayetano Heredia, PO Box 1843, Lima, Peru. iiad@upch.edu.pe
SOURCE:
J-Endocrinol.
2004 Jan; 180(1): 87-95
JOURNAL NAME:
Journal-of-endocrinology,-The
INTERNATIONAL STANDARD SERIAL NUMBER:
0022-0795
PUBLICATION YEAR: 2004
LANGUAGE:
English
COUNTRY OF PUBLICATION:
England
MAIN ABSTRACT: Lepidium
meyenii
(Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and
4500 m in the central Andes. Maca is traditionally employed in the Andean
region for its supposed fertility-enhancing properties.The aim of this
study was to test the hypothesis that Maca can prevent high
altitude-induced testicular disturbances. Adult male rats were exposed for
21 days to an altitude of 4340 m and treated with vehicle or aqueous
extract of Maca (666.6 mg/day). The lengths of the stages of the
seminiferous epithelium and epididymal sperm counts were obtained at 0, 7,
14 and 21 days of exposure. The stages of the seminiferous tubules were
assessed by transillumination. A dose-response study was also performed at
sea level to determine the effect of Maca given to male rats at doses of
0, 6.6, 66.6 and 666.6 mg/day for 7 days on body weight, seminiferous
tubule stages and epididymal sperm count. The length of stage VIII and the
epididymal sperm count were increased in a dose-dependent manner in Maca-treated
rats but treatment reduced the length of stage I. At the highest dose,
sperm count increased 1.58 times, the length of stage VIII increased 2.4
times and the length of stage I was reduced 0.48 times compared with the
value at dose 0. Exposure to high altitude resulted in a reduction in
epididymal sperm count after 7 days and lower values were maintained up to
21 days. Altitude reduced spermiation (stage VIII) to half and the onset
of spermatogenesis (stages IX-XI) to a quarter on days 7 and 14 but
treatment with Maca (666.6 mg/day) prevented these changes. Data on
transillumination and epididymal sperm count in the Maca-treated group
exposed to high altitude were similar to those obtained at sea level. Maca
increased the sperm count on day 21 of exposure to high altitude to values
similar (1095.25 +/- 20.41x10(6) sperm, means +/- S.E.M.) to those
obtained in the Maca-treated group at sea level (1132.30 +/- 172.95x10(6)
sperm). Furthermore, in the Maca-treated group exposed for 21 days to high
altitude, epididymal sperm count was higher than in the non-treated group
at sea level (690.49 +/- 43.67x10(6) sperm). In conclusion, treatment of
rats with Maca at high altitude prevented high altitude-induced
spermatogenic disruption.
MAJOR MESH DESCRIPTORS:
*Altitude-;
*Lepidium-;
*Phytotherapy-;
*Plant-Extracts-therapeutic-use;
*Spermatogenesis-
MINOR MESH DESCRIPTORS:
Dose-Response-Relationship,-Drug;
Models,-Animal;
Random-Allocation;
Rats-;
Rats,-Sprague-Dawley;
Sperm-Count;
Treatment-Outcome
CHECK TAGS:
Animals;
Comparative-Study;
Male;
Research-Support,-Non-U.S.-Gov't
PUBLICATION TYPE:
Journal-Article
SUBHEADINGS:
therapeutic-use
CAS REGISTRY NUMBER:
0
PRIME NAME OF SUBSTANCE:
Plant-Extracts
JOURNAL CATEGORY:
Endocrinology
SUBSET:
Index-Medicus
UPDATE CODE:
20041117
ENTRY DATE:
20040107
REVISION DATE:
20041117
COMPLETION DATE:
20040310
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
14709147
PUBLISHING MODEL:
Print
RECORD FEATURES:
ABSTRACT (AB)
